GASTROPROTECTIVE EFFECTS OF THE AQUEOUS EXTRACT OF SIMAROUBAAMARAAUBLET (SIMAROUBACEAE) STEM BARK ON EXPERIMENTALLY INDUCED GASTRIC ULCERS IN RODENTS

Abstract

SimaroubaamaraAublet stem bark decoction has been traditionally used in Brazil to treat malaria, inflammation, fever,
abdominal pain, diarrhea, wound and as tonic. The aim of this study was investigate the gastroprotective effects of the aqueous
extract of S. amarastem bark (SAAE) on different ulcer models induced in rodents. The SAAE was obtained by decoction and
analyzed by high performance liquid chromatography (HPLC). Acute ulcer was induced by ethanol and indomethacin and the
chronic model by acetic acid. HPLC analyze quantified condensed and hydrolysable tannins. Oral administration of SAAE (100,
250 and 500 mg/kg) inhibited ethanol and indomethacin induced ulcers. In the chronic model, SAAE (500 mg/kg) promoted reepithelization,
increased cell proliferation and restored glandular secretory activity of the gastric mucosa.The SAAE showed
significant gastroprotective effects in the ulcerogenic models induced in rats. It restored glandular secretory activity and
probablyprevented the oxidative damage at the same time that increased regenerative and reparative capacities of the gastric
mucosa.