SYNTHESIS OF 7-SUBSTITUTEDTHIOCARBAMIDO-1-METHYL-5-PHENYL-3H- 1,4-BENZODIAZEPINE-2-ONE

Abstract

Heterocyclic nucleus containing drugs showed remarkable and noticeable pharmacodynamics and pharmacokinetics
properties . They generated their own identity and importance in medicinal, pharmaceutical, agricultural and drug sciences.
Benzonido and pyridino, dithiazolo, quinolino and alkylaminoheterocycles showed important applications in industrial,
medicinal,pharmaceutical and drug chemistry. Considering all these facts into consideration, recently in this laboratory
interactions of 7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepine-2- one (1)was carried out with variousthiourea(2)by using
inisopropanol medium to isolate 7-substitutedthiocarbamido-1-methyl-5-phenyl-3H-1,4-benzodiazepine-2-one(3). The
justification and identification of the structure of these newly synthesized compounds had been established on the basis of
chemical characterization, elemental analysis and through spectral data.