ANALGESIC EFFECTS OF THE ETHANOLIC EXTRACT OF FLOWERS OF SPATHODEA CAMPANULATA STUDIED IN ALBINO MICE

Abstract

The analgesic effect and possible mechanism of action of 100-500 mg/kg of the ethanolic flower extract of Spathodea campanulata were investigated in different experimental models of analgesia using the Acetic acid induced writhing test, formalin test and Tail immersion methods. Oral pre treatment with 100-500 mg/kg of Spathodea campanulata caused significant and dose related analgesic effect in the treated rats in all the experimental models used. This analgesia was mediated via central and peripheral mechanisms. Overall, the results showed that Spathodea campanulata possesses analgesic effect which lends support to its folkloric use in the local management of pain.