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Abstract

Tablet is the most popular among all dosage forms existing today because of its convenience of self administration, compactness and easy manufacturing; however in many cases immediate onset of action is required than conventional therapy. To overcome these drawbacks, immediate release pharmaceutical dosage form has emerged as alternative oral dosage forms. There are novel types of dosage forms that act very quickly after adminstration. The basic approach used in development tablets is the use of superdisintegrants like Cross linked carboxymelhylcellulose (Croscarmeliose), Sodium starch glycolate (Primogel, Explotab), Polyvinylpyrrolidone (Polyplasdone) etc. which provide instantaneous disintegration of tablet after administration. The development of immediate release tablets also provides an opportunity for a line extension in the market place. A wide range of drugs (e.g., cardiovascular drugs, analgesics, antihistamines, and drugs can be considered candidates for this dosage form. As a drug entity nears the end of its patent life, it is common for pharmaceutical manufacturers to develop a given drug entity in a new and improved dosage form. Immediate release dosage form allows a manufacturer to extend market exclusivity, while offering its patient population a more convenient dosage form or dosing regimen. Now a day, immediate release formulations are similar to many sustained release formulations that are now commonly available.

Keywords

Immediate release Superdisintegrants Direct compression Wet Granulation

Article Details

How to Cite
Nitan, B., Kulwinder, S. K., Neeraj, B., & Pooja, S. (2013). RECENT ADVANCEMENT IN IMMEDIATE RELEASE DRUG DELIVERY SYSTEMS: A REVIEW . International Research Journal of Pharmaceutical and Applied Sciences, 3(1), 136-141. Retrieved from https://www.scienztech.org/index.php/irjpas/article/view/441