2 - PYRAZOLINE: A PHARMACOLOGICALLY ACTIVE MOIETY

Abstract

The aim of this review was to collate literature work reported by many researchers on 2pyrazoline derivatives for their varoius pharmacological activities and also to report the recent efforts made on this moiety. This interesting group of compound has diverse biological activities such as antimicrobial, antimyobacterial, antiamoebic, antiviral, antihelminthic, antiparasitic, insecticidal, anti-inflammatory, analgesic, anticonvulsant, antidepressant, anticancer, anaesthetic, antidiabetic, antioxidant, ACE inhibitory, hypotensive, cholesterol inhibitory and selective activity such as Nitric oxide synthase (NOS) inhibitor and Cannabinoid CB1 receptor antagonists activity. The purpose of this review is to provide an overview of diverse pharmacological activities of 2-pyrazoline moiety. Various derivatives of 2-pyrazoline have been analysed in this review for varying pharmacological activities.